Closing #2330 , but leaving this here so it'll get picked up one day if needed. related #2318.
https://groups.google.com/forum/m/#!topic/pydata/ksIPthf2NJI
Comment From: jreback
should raise in constructors on little endian
occasionally causes hard to find issues
should be simple checks
Comment From: jorisvandenbossche
Closing in favor of https://github.com/pandas-dev/pandas/issues/4737